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primarily in Korea, China, and eastern Russia The Seoul viruses produce a less severe form and are found primarily in Korea and China The Puumala and Dobrava viruses are found in Scandinavia and Europe and are associated with a milder form of the syndrome, nephropathia epidemica, which usually presents with fever, headache, gastrointestinal symptoms, and impaired renal function The Sin Nombre (Muerto Canyon, Four Corners) virus is the most common hantavirus infection in the United States and is one of the viruses responsible for the hantavirus pulmonary syndrome, seen in the southwestern United States Between 1993 and 2006, 438 cases have been reported in 32 states Outbreaks are currently being reported from Central and South America Hantavirus pulmonary syndrome (the mean incubation period for which is 18 days) begins as a nonspecific febrile illness followed by a severe increase in pulmonary vascular permeability, leading to respiratory failure, and rapid progression to a shock-like state Hematologic features include thrombocytopenia, hemoconcentration, and leukocytosis, with abnormal lymphocytes and immature myeloid cells in the peripheral smear Clinical similarities, including a propensity toward renal involvement exist between the New World hantaviruses and their Old World counterparts Diagnosis can be made serologically, with most patients having both IgM and IgG antibodies at the time of presentation; by immunohistochemical staining; or by PCR amplification of viral tissue DNA A viral load assay correlates with severity of disease among patients under intensive care Because infection is thought to occur by inhalation of rodent wastes, prevention is aimed toward eradication of rodents in houses and avoidance of exposure to rodent excreta in rural settings No treatment has been established as definitely effective for hantavirus pulmonary syndrome Intravenous ribavirin has been used with some success in hemorrhagic fever with renal syndrome, and current studies for its use in hantavirus pulmonary syndrome suggest it is not effective.
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Yellow fever is a zoonotic flavivirus infection transmitted by Aedes and jungle mosquitoes It occurs in an urban and jungle cycle in Africa and in a jungle cycle in South America Epidemics have extended far into the temperate zone during warm seasons The mosquito transmits the infection by first biting an individual having the disease and then biting a susceptible individual after the virus has multiplied within the mosquito s body The incubation period in humans is 3 6 days Adults and children are equally susceptible, though attack rates are highest among adult males because of their work habits Between 5% and 50% of infections are asymptomatic
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1 Mild form Symptoms are malaise, headache, fever, retroorbital pain, nausea, vomiting, and photophobia Relative bradycardia, conjunctival injection, and facial flushing may be present 2 Severe form Severe illness develops in about 15% of those infected with yellow fever Initial symptoms are similar to the mild form, but a brief fever remission lasting hours to a few days is followed by a period of intoxication manifested by fever and relative bradycardia (Faget s sign), hypotension, jaundice, hemorrhage (gastrointestinal, nasal, oral), and delirium that may progress to coma
Leukopenia occurs, although it may not be present at the onset Renal insufficiency with proteinuria is present, sometimes as high as 5 6 g/L, and disappears completely with recovery Abnormal liver function tests are seen, and prothrombin time may be elevated Serologic diagnosis is primarily by measurement of IgM by a capture ELISA Other serologic tests include hemagglutination-inhibition and neutralization PCR protocols are becoming more widely available
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