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tionality of DNA is an important concept (ie, it always appears on exams) Either of the two strands could be written on top (just rotate the paper by 180 ), but if the DNA codes for a protein, the top strand is usually arranged so that it matches the sequence of the RNA that would be made from the DNA (see later) In Fig 4-2, you re looking at a base pair as it would be seen from above, looking down the helix axis The DNA double helix has two grooves the major and the minor If the helix were flat, the major and minor grooves would correspond to the two different flat surfaces represented by the front and back of the flat sheet The major and minor grooves are different size because the two strands come together so that the angle between corresponding points on the phosphate backbone is not 180 Many of the sequence-specific interactions of proteins with DNA occur along the major groove because the bases (which contain the sequence information) are more exposed along this groove The structures shown in Fig 4-1 are for B-form DNA, the usual form of the molecule in solution Different double-helical DNA structures can be formed by rotating various bonds that connect the structure These are termed different conformations The A and B conformations are both right-handed helices that differ in pitch (how much the helix rises per turn) and other molecular properties Z-DNA is a left-handed helical form of DNA in which the phosphate backbones of the two antiparallel DNA strands are still arranged in a helix but with a more irregular appearance The conformation of DNA (A, B, or Z) depends on the temperature and salt concentration as well as the base composition of the DNA Z-DNA appears to be favored in certain regions of DNA in which the sequence is rich in G and C base pairs.

This property grid will help you set properties much faster First, let s say you are setting the Name property of a number of query items You can just type in the name of the first query item in the list and then click the down arrow on your keyboard to move to the next to set its name Another nice feature is the ability to copy cell values for a property by using the pull-down cell copier If you set a value for a property in the first row, you can click and drag that control across the subsequent rows to copy the value from the first cell This is very similar to how a spreadsheet works This particular feature is helpful if you need to set the same usage or format for a lot of query items Another feature of the grid is the column filter, which is another spreadsheet-like feature If you click the filter icon in the column header, you will see a drop-down list of all the values that the selected objects have for that property If you select one of those values, only the objects that have that setting for that property will remain visible This can be quite handy if you have a long list of query items First, you can go through them all to set their names and their usages Then you can filter only for those with a usage of Fact so that you can set the Regular Aggregate property for each of those

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There is no absolute standard for position in the Universe, nor is there an absolute standard for velocity Another way of saying this is that any reference frame is just as valid as any other as long as acceleration does not take place The notions of the center of the Universe and at rest are relative If we measure position or velocity, we must do so with respect to something, such as Earth or the Sun or a space ship coasting through the void

Figure 4-2

NOTE If you select multiple objects of different classes, such as a namespace, a query subject, and

DNA has a MAJOR AND MINOR GROOVE because the bases attach at an angle that is not 180 apart around the axis of the helix The major groove has more of the bases exposed Sequence-specific interactions with DNA often occur along the major groove Since the helix is right-handed, the next ribose shown is above the last one

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