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Leukopenia is characteristic and elevated transaminases are found frequently in dengue fever Thrombocytopenia, increased fibrinolysis, and hemoconcentration occur more often in the hemorrhagic form of the disease Liver function abnormalities are nearly universal The nonspecific nature of the illness mandates laboratory verification for diagnosis, usually with IgM and IgG ELISAs Virus may be recovered from the blood during the acute phase, and PCR may be diagnostic during the first few days of infection Immunohistochemistry for antigen detection in tissue samples can also be used

This is accomplished by drawing a bright and shining line between the public interface of a class and its private implementation The public interface is a contract issued by your class that consists of two parts The first part says, I promise to be able to do this work Specifically, you ll see that a public interface says, Call this method, with these parameters, and I ll do this work, and return this value The second part says, You are allowed to access these values (and no others) C# implements this second part of the interface through properties (discussed in 8) A client can rely on a public interface not to change If the public interface does change, the client must be recompiled and perhaps redesigned On the other hand, the private implementation is, as its name implies, private to the server.

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Hantaviruses are rodent-borne enveloped RNA bunyaviruses with several distinct serotypes These differ in rodent hosts, geographic distribution, and degree of pathogenicity for humans They cause two major clinical syndromes: hemorrhagic fever (discussed above) and the hantavirus pulmonary syndrome Each year, over 150,000 cases of these two syndromes occur globally Aerosols of virus-contaminated rodent urine and perhaps feces are thought to be the main vehicle for transmission to humans The ubiquity of hantaviruses is becoming recognized, with descriptions of infections from North and South America and additional infections from Europe and Asia The Hantaan serotype viruses cause severe hemorrhagic fever with renal syndrome and are found

Usual complications include depression, chronic fatigue, pneumonia, bone marrow failure, hepatitis, iritis, orchitis, and oophoritis Neurologic complications such as encephalitis and transverse myelitis are less often reported Dengue

Sudden onset of severe headache, aching in legs, and tachycardia Brief (1 day) remission, followed by bradycardia, hypotension, jaundice, hemorrhagic tendency Proteinuria, leukopenia, bilirubinemia, bilirubinuria Rare and potentially fatal reactions to vaccination

The designer of the server class is free to change how it does the work promised in the public interface, as long as it continues to fulfill the terms of its implicit contract: it must take the given parameters, do the promised work, and return the promised value and allow access to the public properties For example, you might have a public method NetPresentValue( ) that promises as follows: Give me a dollar amount and a number of years, and I ll return the net present value How you compute that amount is your business; as long as you return the net present value given a dollar amount and number of years, the client doesn t care whether you look it up in a table, compute the value, or ask your friend who is really good at math.

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