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Henna MR et al Hormonal cryptorchidism therapy: systematic review with metanalysis of randomized clinical trials Pediatr Surg Int 2004 May;20(5):357 9 [PMID: 15221359] Kolon TF et al Cryptorchidism: diagnosis, treatment, and longterm prognosis Urol Clin North Am 2004 Aug;31(3):469 80 [PMID: 15313056]

The differential diagnosis for hemorrhagic fever includes meningococcemia or other septicemias, Rocky Mountain spotted fever, dengue, typhoid fever, and malaria The likelihood of acquiring hemorrhagic fevers among travelers is low

Certain arenaviruses (the Lassa pathogen, Junin virus in its viscerotropic phase, Machupo virus) and bunyaviruses (provisionally, the Congo-Crimean Hemorrhagic Fever and Rift Valley Fever pathogens) respond to ribavirin if it is started promptly: 30 mg/kg as loading dose, followed by 16 mg/kg every 6 hours for 4 days and then 8 mg/kg every 8 hours for 3 days The filoviruses and the flaviviruses do not respond to ribavirin Vaccines are needed for these pathogens The successful yellow fever vaccine is discussed below A live attenuated Junin vaccine is undergoing trials A formalin-inactivated vaccine against the Rift Valley Fever pathogen is in use and a live-attenuated vaccine is under development Therapeutic interventions that target the hematologic system are either ineffective or only marginally effective Future studies will target combining antivirals with immune mediators

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A class typically defines a number of methods to do the work of that class. A Dog class might contain methods for barking, eating, napping, and so forth. An Employee class might contain methods for adjusting salary, submitting annual reviews, and evaluating performance objectives. Methods can manipulate the state of the object by changing the values in member fields, or a method could interact with other objects of its own type or with objects of other types. This interaction among objects is crucial to object-oriented programming. For example, a method in Dog might change the state of the Dog (for example, a Feed method might change the Dog s weight), interact with other Dogs (Bark and Sniff), or interact with People (BegForFood). A Product object might interact with a Customer object, and a Video object might interact with an EditingWindow object. Designing a good C# program is not unlike forming a good team; you look for players (or objects, in the case of a program) who have different skills and to whom you can delegate the various tasks you must accomplish. Those players cooperate with one another to get the job done. In a good object-oriented program, you will design objects that represent things in your problem domain. You will then divide the work of the program among your objects, assigning responsibility to objects based on their ability.

Dengue is due to a flavivirus transmitted by the bite of the Aedes mosquito It may be caused by one of four serotypes widely distributed between the tropics of Capricorn and Cancer An estimated 50 100 million cases of dengue fever and several hundred thousand cases of dengue hemorrhagic fever occur each year The incubation period is 3 15 days (usually 7 10 days) When the virus is introduced into susceptible populations, usually by viremic travelers, epidemic attack rates range from 50% to 70% Transmission occurred in the United States in southern Texas and nearby Mexican border towns in 1986 and 1999 In 2001, a large outbreak in Hawaii was traced to a traveler returning from French Polynesia In 2005, the first outbreak of dengue hemorrhagic fever in the United States was documented The outbreak was binational and involved more than 6000 persons in Brownsville, Texas and Matamoros, Mexico with primarily serotype 2 In addition, there were 96 travel-related dengue cases among US

Persons with symptoms compatible with those of any hemorrhagic fever and who have traveled from a pos-

residents in 2005 Severe epidemics of dengue hemorrhagic fever (serotype 3) occurred over the past 20 years in East Africa, Sri Lanka, and Latin America

The heart of object-oriented design is establishing relationships among the classes. Classes interact and relate to one another in various ways. The simplest interaction is when a method in one class is used to call a method in a second class. For example, the Manager class might have a method that calls the UpdateSalary method on an object of type Employee. We then say that the Manager class and the Employee class are associated. Association among classes simply means they interact.

hemorrhagic fever or shock with concomitant bacterial infection is associated with advanced age, higher fever, gastrointestinal bleeding, renal impairment, and altered consciousness

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