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Preexposure prophylaxis with three injections of HDCV intramuscularly (1 mL on days 0, 7, and 21 or 28) or intradermally (01 mL on days 0, 7, and 28, over the deltoid) is recommended for persons at high risk for exposure: veterinarians (who should have rabies antibody titers checked every 2 years and be boosted with 1 mL intramuscularly or 01 mL intradermally if seronegative); animal handlers; laboratory workers; Peace Corps workers; and travelers to remote areas in endemic countries in Africa, Asia, and Latin America An intradermal route is available for preexposure prophylaxis only Immunosuppressive illnesses and agents including corticosteroids as well as antimalarials in particular chloroquine may diminish the antibody response
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Thorough cleansing, debridement, and repeated flushing of wounds with soap and water are important Rabies immune globulin or antiserum should be given as stated below Wounds caused by animal bites should not be sutured
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