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Rubella is a systemic disease caused by a togavirus transmitted by inhalation of infective droplets It is only moderately communicable One attack usually confers permanent immunity The incubation period is 14 21 days (average, 16 days) The disease is transmissible from 1 week before the rash appears until 15 days afterward The clinical picture of rubella is difficult to distinguish from other viral illnesses such as infectious mononucleosis, measles, echovirus infections, and coxsackievirus infections, though arthritis is more prominent in rubella In the United States, endemic rubella and congenital rubella syndrome are eliminated Surveillance of female military recruits suggests, however, that serologic protection against rubella as well as measles and mumps are inadequate The principal importance of rubella lies in its devastating effects on the fetus in utero, producing teratogenic effects and a continuing congenital infection Congenital rubella syndrome continues to occur in parts of the developing world at rates equivalent to those reported from the industrialized world during the prevaccine era More than 100,000 cases occur annually in the developing world Recent outbreaks occurred in Italy and Brazil, with Recife, Brazil reporting 49 cases of congenital rubella syndrome between 1998 and 2001 The majority of recent cases of congenital rubella syndrome in the United States occurred among immigrants; between 2001 and 2004 only four cases were reported to the Centers for Disease Control and Prevention (CDC) (three among immigrants)

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During the febrile period, paralysis may develop or progress Mild weakness of small muscles is more likely to regress than is severe weakness of large muscles Bulbar poliomyelitis carries a mortality rate of up to 50% New muscle weakness and pain may develop and progress slowly years after recovery from acute paralytic poliomyelitis This entity is called postpoliomyelitis syndrome and presents with signs of chronic and new denervation, is not infectious in origin, and patients do not shed the virus The syndrome is associated with increasing dysfunction of surviving motor neurons Different immune modulators such as prednisone, interferon, and intravenous immunoglobulin have been tested for treatment of postpoliomyelitis syndrome but have not shown clear benefits Series that report increased incidences of multiple sclerosis or other motor neuron diseases among poliomyelitis survivors need to be evaluated in the context of what is known about the postpoliomyelitis syndrome Although bulbar poliomyelitis causes the greatest threat to life, it is rarely responsible for permanent damage among surviving patients

Centers for Disease Control and Prevention (CDC) Brief report: Conclusions and recommendations of the Advisory Committee on Poliomyelitis Eradication Geneva, Switzerland, October 2005 MMWR Morb Mortal Wkly Rep 2005 Nov 25;54(46):1186 8 [PMID: 16323363] Centers for Disease Control and Prevention (CDC) Progress toward interruption of wild poliovirus transmission worldwide, January 2004 March 2005 MMWR Morb Mortal Wkly Rep 2005 Apr 29;54(16):408 12 [PMID: 15858461] Howard RS Poliomyelitis and the postpolio syndrome BMJ 2005 Jun 4;330(7503):1314 8 [PMID 15933355] Katz SL Polio new challenges in 2006 J Clin Virol 2006 Jul; 36(3):163 5 [PMID: 16679055] Laassri M et al Analysis of reversions in the 5'-untranslated region of attenuated poliovirus after sequential administration of inactivated and oral poliovirus vaccines J Infect Dis 2006 May 15;193(10):1344 9 [PMID: 16619180]

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After you write your program in an editor and save it to disk, you must compile it. Compiling is the process of turning the code that you can read into code that the machine can read. For that, you need a compiler. Then, once you ve compiled the program, you need to run and test it. The job of the compiler is to turn your source code into a working program. It turns out to be just slightly more complicated than that because .NET uses an intermediate language called Microsoft Intermediate Language (MSIL, sometimes abbreviated as IL). The compiler reads your source code and produces MSIL. When you run the program, the .NET Just In Time (JIT) compiler reads your MSIL code and produces an executable application in memory. You won t see any of this happen, but it s a good idea to know what s going on behind the scenes.

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