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There are three recognizable clinical syndromes 1 Perinatal disease and CMV inclusion disease Congenital CMV infection is the most common congenital infection in developed countries, affecting about 1% of all neonates About 10% of infected newborns born to mothers with primary CMV infection during pregnancy will be symptomatic with CMV inclusion disease It is characterized by jaundice, hepatosplenomegaly, thrombocytopenia, purpura, microcephaly, periventricular CNS calcifications, mental retardation, and motor disability Hearing loss develops in greater than 50% of infants who are symptomatic at birth Most patients with congenital CMV infection are asymptomatic, but neurologic deficits may ensue later in life Perinatal infection acquired through breast-feeding or blood products typically shows a benign clinical course

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characteristic CMV histopathologic findings of intranuclear ( owl s eye ) and intracytoplasmic inclusions c Pulmonary CMV CMV pneumonitis characterized by cough, dyspnea, relatively little sputum production, and chest radiograph findings consistent with interstitial pneumonia occurs in transplant recipients with a mortality rate up to 60 80%, and less commonly in AIDS patients In AIDS patients, the significant morbidity and mortality appear to be diminished by the use of antiretroviral therapy High-titer CMV immunoglobulin may be effective in preventing CMV pneumonia in seronegative recipients d Neurologic CMV Neurologic syndromes associated with CMV include polyradiculopathy, transverse myelitis, ventriculoencephalitis, and focal encephalitis The encephalitis has a subacute onset in patients with advanced AIDS and is usually associated with disseminated CMV infection CMV can be isolated in the cerebrospinal fluid in cases of transverse myelitis or disseminated disease

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2 Disease in immunocompetent persons a Acute acquired CMV infection Akin to EBV-associated infectious mononucleosis, this syndrome is characterized by fever, malaise, myalgias and arthralgias (but rarely exudative pharyngitis or cervical lymphadenopathy), splenomegaly, atypical lymphocytes, and abnormal liver function tests The mean duration of symptoms is 7 8 weeks Typically, leukopenia is followed by leukocytosis Heterophil antibody is absent Transmission occurs by sexual contact, in breast milk, via respiratory droplets among nursery or day care center attendants, and by transfusions of blood Complications include mucosal gastrointestinal damage, encephalitis, Guillain Barr syndrome, pericarditis, and myocarditis b Other associations with CMV Other clinical syndromes that are reported to be associated with CMV and whose role in pathogenesis requires further elucidation include inflammatory bowel disease, atherosclerosis and myocardial infarction, and breast cancer (the last of these is associated with a higher risk of late CMV disease in life) 3 Disease in immunocompromised persons Tissue and bone marrow transplant patients are mainly at risk in the first 100 days after allograft transplantation and in particular when graft-versus-host disease or CMV seropositivity is present HIV-infected patients may show numerous manifestations, described below, and these occur most prominently when the CD4 count is < 100 cell/mcL or when the HIV viral load is > 10,000 copies/mcL CMV is itself immunosuppressive and promotes other infections such as Pneumocystis and Aspergillus pneumonia It may contribute to transplanted organ dysfunction, in particular, hepatitis, which can mimic organ rejection The so-called CMV syndrome in renal transplant patients resembles mononucleosis among new transplant recipients a CMV retinitis Retinitis occurs in AIDS patients with CD4 counts < 50 cells/mcL and on occasion among the immunocompetent (among whom the rate of retinal detachment is lower) Ophthalmologic documentation of neovascular, proliferative lesions ( pizza-pie retinopathy) is required for diagnosis With HAART, the frequency of retinitis is reduced, CD4 counts are less predictive, and active disease may be reversible Immune restoration with HAART is associated with CMV vitreitis and CMV-associated cystoid macular edema Infants with CMV retinitis tend to have more macular than peripheral disease CMV retinitis may also develop in persons who have undergone heart transplantation; it is usually asymptomatic b Gastrointestinal and hepatobiliary CMV Serious gastrointestinal CMV disease occurs in AIDS (usually with CD4 counts < 100 cells/mcL) and after organ transplantation, cancer chemotherapy, or corticosteroid therapy Esophagitis presents with odynophagia; small bowel disease may mimic inflammatory bowel disease or may present as ulceration or perforation Colonic CMV disease causes diarrhea, hematochezia, abdominal pain, fever, and weight loss CMV has been identified often with other pathogens such as Cryptosporidium in up to 15% of patients with AIDS cholangiopathy Diagnosis is made by mucosal biopsy showing.

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