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The FDA now encourages inclusion of data on the effect of studied drugs on women and minorities in clinical data submitted on new drug applications. Although an explicit racial and gender classi cation, the requirement does not act like a subsidy to a racial group in the same way that the NIH funding requirement does. Given the FDA s duty to ensure that drugs are safe and effective, it is reasonable to require that a drug is safe and effective for all the persons likely to be given the drug, including women and minorities. Without such a requirement the FDA might approve the marketing of a drug that is safe and effective only for persons of the race and gender of the subjects who participated in clinical trials, which traditionally might have excluded women or African Americans. Yet the drug could still be prescribed for African Americans or women, who might respond less well or with more adverse reactions. To avoid that result, Congress might reasonably require that the FDA require new drug and device applicants to submit data on minorities and women as well. No whites or males are hurt by this policy. Indeed, a failure to do so would impose a disproportionately greater health care burden on women and minorities. Such a burden would not be unconstitutional, if it is not the FDA s or applicant s intent to exclude those groups from the study, but rather an effect of pursuing other goals in the design and conduct of the study. Yet it is clearly better policy and certainly constitutional to require that data on women and minorities also be included in new drug applications.

demonstrates the use of nested function calls.} Inputs: movAvgLength1(9),movAvgLength2(19),channelLength(20); value1 = Highest(Average(Close,movAvgLength1),channelLength); value2 = Lowest(Average(Close,movAvgLength1),channelLength); Buy tomorrow at value1 stop; Sell tomorrow at value2 stop; {MyStrategy-1 or MySignal-1 TradeStation 2000i Format The hello world program of EasyLanguage} Inputs: longLength(40),shortLength(40); Buy tomorrow at Highest(High,longLength)stop; Sell tomorrow at Lowest(Low,shortLength)stop;

Example 3.2 illustrated trade-offs between risk and expected cost that may require attention because they can lead to a gain in corporate-level risk ef ciency although they may seem to expose the project to a high level of risk. Often these opportunities do not make themselves obvious: they must be searched for. Further, often they re ect opportunities people are not prepared to take if

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FIGURE 9.24 Phase versus frequency of a rectangular patch that can be used for a type 2 configuration: a = b = 0 6 0 , a1 = 0 41 0 , b1 = 0 24 0 , h = 0 1 0 , r = 1 1, 0 = 1 cm.

Now it s time to play matchmaker. Two chromosomes are selected from the mating pool of Nkeep chromosomes to produce two new offspring. Pairing takes place in the mating population until Npop - Nkeep offspring are born to replace the discarded chromosomes. Pairing chromosomes in a GA can be as interesting and varied as pairing in an animal species. We ll look at a variety of selection methods, starting with the easiest. 1. Pairing from top to bottom. Start at the top of the list and pair the chromosomes two at a time until the top Nkeep chromosomes are selected for mating. Thus, the algorithm pairs odd rows with even rows. The mother

entire ordering process is transformed. Responsibility for inventory replenishment is completely handed over to suppliers. Each of these steps requires greater levels of collaboration, as companies increasingly entrust the responsibilities of placing orders and managing inventory to their partners. Global available-to-promise (ATP) software is used in conjunction with the vendor replenishment and vendor managed inventory phases of Step Three. This software allows companies to reallocate inventory to other customers even after it has been placed on order. Companies should perform an analysis to determine which products should be managed by the supplier company. The effort of moving to a VMI arrangement may outweigh the benefits for small-size shipments, less critical materials, and intermittently used products. The priority of the customer, the value of the material, the speed at which it is consumed, profits, the willingness of the supplier, and other factors will determine whether each product should be moved to VMI.

(6.4)

Interviewers can take days to make up their minds. So you have an opportunity to influence interviewers even after you ve left the interview. If the interviewers are deliberating between you and perhaps one other candidate, then a follow-up letter can just tip the balance. A few well-crafted paragraphs can well be the difference between success and failure. Consider carefully whether to use e-mail or an old-fashioned letter in an envelope with a stamp on it. E-mail can be useful if speed is of the essence for example, you know the interviewers have seen all the candidates and plan to make up their minds quickly. On the other hand, e-mail can easily be ignored. If you have the luxury of time, then a letter is much more likely to make a lasting impression. In your message, try to get across at least two or three of the following points: That you enjoyed the opportunity to meet the interviewer and to hear more about the organisation and the role. That you are very interested in the role, the challenge, the team, or the organisation.

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