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Limited Liability Companies Limited liability companies (LLCs) are a relatively new form of business entity in the United States and have characteristics of both corporations and partnerships LLCs shield their owners (or members) from personal liability for certain of the entity s debts and obligations, in much the same manner as a corporation At the same time, a properly organized LLC can be treated as a partnership for federal income tax purposes, enabling it to enjoy the tax item pass-through and other bene ts of the standard partnership form Registered Limited Liability Partnerships Registered limited liability partnerships (LLPs), a distant relative of the LLC, are a type of general partnership that protects the partners personal assets if another of their partners is sued for malpractice However, the assets of the partnership itself remain at risk, as do the personal assets of the accused partner, and all partners still retain the standard joint-and-several liabilities of the partnership (eg, lease obligations and bank loans) Limited Partnerships The limited partnership form has proliferated in recent years as a vehicle for raising capital for a particular project or undertaking Limited partnerships are particularly common in the leasing and oil and gas industries Prior to the Tax Reform Act of 1986, the limited partnership form also served as the organizational structure for a number of tax shelters Limited partners risk losing their limited liability the more they participate in the management or control of the partnership s activities, thus reducing the attractiveness of the limited partnership structure for some potential partners See Section 426 for further discussion of limited partnerships Joint Ventures Partnerships are often encountered in the formation and operation of joint ventures In a typical corporate joint venture, two or more entities form a partnership to undertake a speci c business project, often for a speci c, agreed-upon period Each party s contributions to the venture may vary widely from case to case For example, one corporation may provide technology, personnel, or facilities while the other contributes only the cash or other operating capital required for the undertaking Alternatively, the venturers may jointly provide some or all of these elements In any event, the entities form an enterprise that will function as a partnership, even if that partnership has the legal status of a corporation See Section 428 for further discussion of joint ventures.

Regarding the clinical ef cacy of a PDE-5 inhibitor several tools are used in clinical trials Regarding the general assessment question (GAQ): Has the treatment you have been taking improved your erections This ef cacy tool does not really tell whether the patient is able to attain an erection suf cient for sexual intercourse or not This relatively weak ef cacy measure is widely used, especially by pharmaceutical companies, because usually it yields the highest success rates

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(c) TAX CONSIDERATIONS Even though a partnership is not considered a separate taxable entity for purposes of paying and determining federal income taxes, it is treated as such for purposes of making various elections and for selecting its accounting methods, taxable year, and method of depreciation

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Currently the PDE system includes 11 families, with a total of more than 50 splice variants (isoforms) [34 40] The distribution and density of PDEs varies among the different tissues The PDEs catalyze the breakdown of either cGMP or cyclic adenosine monophosphate (cAMP), which are both second messengers with speci c physiologic functions By hydrolyzing the phosphodiesterase bond of cAMP or cGMP, these second messengers are converted to the biologically-inactive monophosphates, resulting in termination of their physiologic functions In addition to PDE-5, which is the most abundant one in the corpus cavernosum, to date at least 13 other PDEs have been identi ed in the cavernous bodies: PDE-1A, PDE-1B, PDE-1C, PDE-2A, PDE3A, PDE-4A, PDE-4B, PDE-4C, PDE-4D, PDE-7A, PDE-8A, PDE-9A, PDE-10A [39,40] Apart from their direct impact on cavernous function, PDE-4 and -5 inhibitors also inhibit proliferation and migration of smooth muscle cells [37] PDE-3 and PDE-4 inhibition can reduce restenosis after angioplasty procedures, individually, or by acting synergistically, and are therefore under investigation for their potential on angiogenesis [37]

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