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An interface is a connection for hooking to another system (an external interface) or for hooking one system component to another (an internal interface). The interface of a system contains both a logical element and a physical element (or link) that are responsible for carrying items (electromechanical energy or information) from one component or system to another. The interface must ensure that the item is delivered on time and in the same form as the item was received. The development of the interface architecture is quite similar to the development of the allocated architecture of a system, as shown in Figure 10.1. [See Appendix B for the entire IDEF0 (Integrated De nition for Function Modeling) model for engineering a system.] The functions of de ning requirements as well as the functional, physical, and allocated architectures are present. The only new function is the evaluation and selection of a high-level interface architecture; Section 10.3 de nes and discusses the three major alternate interface architectures in use today in communication and computer systems. This high-level architecture for the interface is analogous to the concept selection for the system design. Before proceeding very far in the development of a system, high-level concepts, each having a different operational concept, are posited and evaluated. This decomposition of functions for developing an interface architecture assumes that the functional process will be revisited several times in whole or in part. As interface changes arrive from the process responsible for the system s allocated architecture, the relevant functions for developing the interface

All of this software sophistication is of course of little use unless the staff of each trussed rafter manufacturer are able to fully exploit it. It is here that the main differences now exist between trussed rafter manufacturers. All have the software available to them but few use all aspects of their plate supplier s software packages. Computer-aided drafting, for instance, is still not commonplace with manufacturers with the exception of those using the Wolf system, whose program seems to be particularly graphically oriented, but all use the quoting facility (although not perhaps the word processing element) (see point (3) on page 125), and all use the engineering

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Gathering and collecting these metrics is straightforward in test management tools that provide reporting capabilities. In contrast, collecting these or similar metrics from disconnected spreadsheets in multiple shared drives proves to be a daunting and time-consuming task. These metrics assist in estimating the costs for future testing cycles and identifying areas of deficiencies associated with the creation of test cases.

Full-table tourneys (9 or 10 players): 50 percent of entry fees to first place 30 percent to second place 20 percent to third place Short-handed tourneys (5 or 6 players): 65 percent of entry fees to first place 35 percent to second place Head s-up tourneys (2 players): 100 percent of entry fees to first place Don t you feel like a middle child coming in second place

maintaining primary jurisdiction48 However, it later states that a device used concomitantly with a drug to directly activate or to augment drug effectiveness, such as laser activation of oxsoralen for psoriasis, is regulated by CDRH as a separate entity49 Assuming the polymers or nanoparticles are activated by infrared light, it is unclear exactly how the delivery system would be regulated FDA officials responsible for classification have acknowledged the many shades of gray involved in classifying novel drug delivery products50 Thus, without updated guidelines governing novel combination products such as drug delivery systems and drugs combined with monoclonal antibodies, there could be an increasing number of jurisdictional disputes (see Figure 61) The time-intensive process associated with determining primary jurisdiction will result in increased regulatory delay for nanomedical products.

A Portrait of the Artist as a Very Big (or Little) Number Film and record producers make a point of telling us how much was spent on their works, as if the fact that the remake of Planet of the Apes cost $100 million is important to anyone besides the studio accountants. And it is, isn t it When you see that number, are you completely indifferent to it It s a big number, man. A hundred million of anything gets my attention. (If they d used 100 million apes to make that movie, I d have to see it, probably twice, to make sure I didn t miss a single ape. To hell with the people; I can see 100 million of those any time I want.)

In the long term, nanotechnology could produce a whole new class of products that will defy easy classification as drugs, devices, biologics, or combination products The current distinctions between chemical, mechanical, and biological activity will be rendered useless First, at the atomic and molecular level, there is no distinction between drugs and biologics, as currently defined Since biological organisms are comprised of chemical elements, primarily carbon, oxygen, hydrogen, and nitrogen, biological interactions can be characterized as chemical interactions Second, at the atomic level, the distinction between drugs and devices is worn away At the macro level, a mechanical interaction, which conjures images of machinery or tools, can be conceptualized as a change in force and matter but not a change in the chemical composition of the substance However, when the focus is on the rearrangement of atoms, it makes no sense to distinguish between chemical and physical forces.

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