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decrease in PFK and lactate dehydrogenase among other enzymes following 6 months of training A potential explanation for the observed decrease in enzyme content resulting from long-term strength training is the dilution effect caused by the increase in skeletal muscle mass as re ected in changes in ber cross-sectional area This increased contractile protein content will naturally result in a decrease in enzyme content or activity per unit of muscle mass (milligram of tissue) Consistent with the observation of a decrease in enzyme content, MacDougall et al (1979) were the rst to demonstrate a decrease in mitochondrial volume density following 6 months of strength training In this study, morphometric analyses of muscle biopsies from the triceps brachii indicated that training resulted in a signi cant (26%) reduction in mitochondrial volume density and a similar (25%) reduction in the mitochondrial volume to myo brillar volume ratio.

Accordingly, while the IIA believes that there is an ideal reporting structure with functional reporting to the Audit Committee and administrative reporting to the CEO, other relationships can be effective if there are clear distinctions between the functional and administrative reporting lines and appropriate activities are in each line to ensure that the independence and scope of activities is maintained Internal auditors are expected to use professional judgement to determine the extent to which the guidance provided in this advisory should be applied in each given situation 4 The Standards stress the importance of the chief audit executive reporting to an individual with sufficient authority to promote independence and to ensure broad audit coverage The Standards are purposely somewhat generic about reporting relationships, however, because they are designed to be applicable at all organizations regardless of size or any other factors.

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Table 10.2 Precautions for athletes to decrease the risk of developing upper respiratory tract infection (URTI). Space high intensity and prolonged exercise session and race events as far apart as possible Avoid overtraining and chronic fatigue Maintain a well-balanced diet Get adequate sleep Take 500 mg day 1 vitamin C during periods of heavy training Ensure adequate carbohydrate intake during intense prolonged exercise

This decrease was accompanied by signi cant increases in ber crosssectional area for both FT (33%) and ST (27%) bers, which suggests that strength training can result in a dilution of the mitochondrial volume density through the increase in myo brillar protein content typical of muscle hypertrophy Similar ndings were later con rmed by Luthi et al (1986), who reported a decrease (96%) in the volume density of mitochondria only after 6 weeks of training with only a modest increase (84%) in both cross-sectional area of the vastus lateralis muscle and myo brillar volume (10%) Indeed, the decrease in mitochondrial volume density was caused by the dilution effect mentioned above and not by the morphologic or ultrastructural changes intrinsic to the mitochondria as the surface densities of inner and outer mitochondrial membranes remained unchanged.

Factors that make one size fits all unattainable include organization size, and type of organization (private, governmental, corporate) Accordingly, the CAE should consider the following attributes in evaluating the appropriateness of the administrative reporting line Does the individual have sufficient authority and stature to ensure the effectiveness of the function Does the individual have an appropriate control and governance mindset to assist the CAE in their role Does the individual have the time and interest to actively support the CAE on audit issues Does the individual understand the functional reporting relationship and support it 5 The CAE should also ensure that appropriate independence is maintained if the individual responsible for the administrative reporting line is also responsible for other activities in the organization, which are subject to internal audit For example, some CAEs report administratively to the Chief Financial Officer, who is also responsible for the organization s accounting functions.

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Interface Inc. (1999)

With mitochondria being the cellular energy powerhouse driving oxidative metabolism, it is not surprising that oxidative enzyme content is also reduced (or at least not increased) following strength training Schantz and Kallman (1989) compared muscles from untrained with strengthtrained subjects and found no differences in the levels of enzymes involved in the citric acid cycle, fatty acid oxidation, or glycolysis No differences.

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