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Ordinarily, hydrogen ion excretion associated with phosphate and other filtered buffers is no greater than about 40 mmol/day This amount is not sufficient to balance the normal hydrogen ion production of 50 100 mmol/day or take care of any unusually high (usually pathological) production of acid loads To excrete the rest of the hydrogen ion and achieve balance, there is a second means of excreting hydrogen ions that involves ammoniagenesis and excretion of hydrogen ions as ammonium Quantitatively, far more hydrogen ions can be excreted by means of ammonium than via organic buffers There are many nuances to hydrogen ion excretion via ammonium, but the basic concepts are straightforward As described in 5, the catabolism of protein and oxidation of the constituent amino acids by the liver generates CO2, water, urea, and some glutamine Protein catabolism, which occurs constantly, even in starvation, requires the continuous excretion of urea by the kidneys to prevent uremia Although, as described earlier, metabolism of the side chains of amino acids can lead to the addition of acid or base, the processing of the core of an amino acid the carboxyl group and amino group is acid-base neutral After many intermediate steps, processing of the carboxyl group of the amino acid produces a bicarbonate, and processing of the amino group produces an ammonium ion Processing does not stop there, however, because ammonium in more than miniscule levels is quite toxic Ammonium is further processed by the liver to either urea or glutamine In both cases, each ammonium consumed also consumes a bicarbonate Thus, the bicarbonate produced from the carboxyl group is just an intermediate, consumed as fast as it is made, and the process as a whole is acid-base neutral We can write this process as follows: 2 amino acids (1oxygen) 2NH4+ 1 2HCO32 urea or glutamine (1CO2 and water).

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A choice many wireless developers are facing today is whether to deploy an intelligent client that has a client application and local data store on the mobile device, or whether to implement a browser-based application Both have advantages and many companies will find themselves needing both to support different user groups If your users only need access to their data and application when connected, and downtime due to coverage holes or powered off devices is not an issue, then a browser-based solution offers many advantages Web-based applications are easy to implement using rapid application development tools Also, devices are inexpensive and easy to manage In fact, you can probably leverage devices the user is already carrying such as smart phones or PDAs

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Players like Hornung, Starr, and Gregg drew on their vast experience to suggest things that could work and also voiced their opinion as to what wouldn t work Studying game film the week before the 1967 NFL Championship against the Dallas Cowboys, for example, Jerry Kramer All-Pro guard for the Packers for many years, noticed that the player across from him, Cowboy defensive tackle Jethro Pugh, stood up at the snap of the ball Kramer thought that in a short-yardage situation, he could get under Pugh and leverage him out of the way He mentioned this to Lombardi, and a play was put in to take advantage of Kramer s observation Although he didn t know it at the time, Kramer s experienced read of Pugh would play a major role in the championship game The Packers won the 1967 title on the last play of the game, with Bart Starr running a quarterback sneak behind Kramer s block on Pugh Despite his reputation as a martinet, Vince Lombardi was a leader who listened to his people Years later, Kramer told me a story that happened the year my father retired as coach of the Packers They were getting ready to play their arch-rivals, the Chicago Bears The challenge was how to block Dick Butkus, the great Chicago middle linebacker The coaching staff put in a blocking scheme that Kramer who had played against Butkus for many years knew wouldn t work When Jerry pointed this out to the coaches, they wouldn t listen, and he was told to block the way it was drawn up Jerry decided then and there to retire at the end of the season

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Compress PDF File Size in ASP.Net using C# and VB.Net | ASPForums.Net
Dim stamper As New PdfStamper(reader, New FileStream( "C:\Users\ dharmendra\Desktop\test1. pdf " , FileMode.Create), PdfWriter.

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LOMBARDI RULE #8

When the urea (or glutamine) is excreted, the body has completed the catabolism of protein in a manner that promotes total body protein nitrogen balance, but is acid-base neutral

However, if the ability to operate offline and to push important information out to users (such as new work orders) is critical, then an intelligent client is the better choice For the most effective intelligent client application, use middleware that supports store-and-forward message queuing and push message delivery

When Lombardi put in a new play on offense, he would ask his veteran players, offensive and defensive, for their opinion as to

regulation of hydrogen ion balanCe / 171

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