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Syphilitic Nerve Deafness This may occur in either early or late syphilitic meningitis and may be combined with other syphilitic syndromes We and our colleagues have had little clinical experience with this disorder and have no pathologic material Treatment of Neurosyphilis The treatment of these tertiary forms of neurosyphilis consists of the administration of penicillin G, given intravenously in a dosage of 18 to 24 million units daily (3 to 4 million units every 4 h) for 14 days Erythromycin and tetracycline, in doses of 05 g every 6 h for 20 to 30 days, are suitable substitutes in patients who are sensitive to penicillin The so-called JarischHerxheimer reaction, which occurs after the rst dose of penicillin and is a matter of concern in the treatment of primary syphilis, is of little consequence in neurosyphilis; it usually consists of no more than a mild temperature elevation and leukocytosis.

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The effects of treatment on certain symptoms of neurosyphilis, especially of tabetic neurosyphilis, are unpredictable and often little in uenced by treatment with penicillin; they require other measures Lightning pains may respond to gabapentin or carbamazepine Analgesics may be helpful, but opiates should generally be avoided Neuropathic (Charcot) joints require bracing or fusion Atropine and phenothiazine derivatives are said to be useful in the treatment of visceral crises In all forms of neurosyphilis, the patient should be re-examined every 3 to 6 months and the CSF should be retested after a 6month interval If after 6 months the patient is free of symptoms and the CSF abnormalities have been reversed (disappearance of cells as well as reduction in protein, gamma globulin, and serology titers), no further treatment is indicated Follow-up should include clinical examinations at 9 and 12 months and another lumbar puncture as part of the latter examination.

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Satisfactory progress is judged by absence of symptoms and further improvement in the CSF These procedures should be repeated every 6 months until the CSF becomes completely negative In the opinion of most experts, a persistent weakly positive serologic (VDRL) test after the cells and protein levels have returned to normal does not constitute an indication for additional treatment Such a CSF formula assures that the disease is quiescent or arrested Others are not convinced of the reliability of this concept and prefer to give more penicillin If at the end of 6 months there are still an increased number of cells and an elevated protein in the uid, another full course of penicillin should be given Clinical relapse is almost invariably attended by recurrence of cells and increase in protein levels.

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For example, in only a few years, many schools have computerized their library card catalogs, and that change is inevitable even imminent for almost all schools Databases, from which information is retrieved by telecommunication on personal computers, are developing with enormous speed When equipment becomes generally available in schools and students learn how to use it, they will gain access to databases and other electronic sources Whereas librarian formerly meant strictly that, today it means library media specialist and more The labels of state licenses in the eld indicate the confusion and the difference of opinion on this specialist s role: school librarian, media generalist, librarian/media specialist, instructional media specialist, materials or media specialist, and audiovisual librarian.

Rapid clinical progression in the face of a negative CSF suggests the presence of a nonsyphilitic disease of the brain or cord A proven maxim for treatment was that a syphilitic patient who has neither abnormal CSF nor aortitis needs no therapy (In the days of arsenical treatment, the therapy put patients at greater risk than did the disease) Finally, it may be said that even with the mild resurgence of the disease due to AIDS, the neurologist nds the various forms of neurosyphilis of more theoretical than practical importance But no other disease has portrayed more vividly the effects of a chronic, continuously active cerebrospinal meningitis on the entire neuraxis..

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