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FIGURE 4.8 The volcano plot of signi cance versus fold change. This gure is a plot of the signi cance (p-value from ANOVA test, on a log-10 scale) against fold change (log-2 ratio), for testing the hypothesis on the differences in gene expression levels between the AML group and the ALL group in the acute leukemia data set. The horizontal line represents a signi cance level threshold of 0.05. The two vertical lines represent the absolute fold-change threshold of 2. The genes plotted in the two A regions are detected as signi cant by both methods, while the genes plotted in region C are detected as insigni cant by both methods. This type of plot demonstrates two types of errors that occur with the ratio-based method: false positive errors plotted in the two D regions, and false negative errors plotted in the B region. A common practice is to identify only the genes plotted in the two A regions as differentially expressed and discard the genes plotted in the B region.

and two sets of real-life data, the speech data vowel and the medical data (which are described in Section 3.7.2.4). The arti cial data of Figure 3.9 consist of two features containing 417 points from two horseshoe-shaped clusters. Vowel data has three features and 871 samples from six classes, while the medical data have nine features and deals with hepatobiliary disorders of 536 patients from four classes. The following quantities were considered for comparing the performance of the RSOM with that of the randomly initialized self-organized map.

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However, it may be necessary to wait until a suf cient degree of weight gain has been achieved before instituting speci c psychological treatments for these disorders Psychotherapy is essential to the treatment of patients with anorexia nervosa and may be provided by professionals from a variety of disciplines In some units, a family therapist is included in the team The dietitian has a central role in supervising the patient s nutritional rehabilitation and may also play a part in nutritional education The occupational therapist may contribute to the patient s dietary rehabilitation, for example supervising her in buying, preparing and cooking meals She may also have a role in running groups on the ward Many inpatients have long histories of anorexia nervosa and the disorder may be complicated by social isolation and delayed psychosocial development.

TABLE P7.2 Censored Data from the Coxian Model for Exercise 7.3a State 1 6.04272 7.62828 7.26209 7.46458 State 2 0.23148 State 3 1.00592

These problems need to be included in the treatment programme and the patient may bene t from rehabilitation in terms of social function, education or employment, sexual relationships and other areas It is essential that the multidisciplinary team meets regularly to review the patient s progress Patients with anorexia nervosa are likely to provoke strong feelings in those who care for them These may include powerful feelings of frustration and anger on the one hand and a wish to protect and rescue the patient on the other These feelings should be understood as counter-transference responses to the patient s dif culties and staff need to be able to resist the temptation to act out their feelings Such acting out can result in ostensibly therapeutic responses which are in fact punitive or humiliating and are ultimately counterproductive.

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