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Urine formation begins with glomerular filtration, the bulk flow of fluid from the glomerular capillaries into Bowman s capsule The glomerular filtrate (ie, the fluid within Bowman s capsule) is very much like blood plasma However, it contains very little total protein The large plasma proteins like albumin and globulins are virtually excluded from moving through the filtration barrier Smaller proteins, such as many of the peptide hormones, are present in the filtrate, but their mass in total is miniscule compared with the mass of large plasma proteins in the blood The filtrate contains most inorganic ions and low-molecular-weight organic solutes in virtually the same concentrations as in the plasma Substances that are present in the filtrate at the same concentration as found in the plasma are said to be freely filtered (Note that freely filtered does not mean all filtered The amount filtered is in exact proportion to the fraction of plasma volume that is filtered) Many low-molecular-weight components of blood are freely filtered Among the most common substances included in the freely filtered category are the ions sodium, potassium, chloride, and bicarbonate; the neutral organics glucose and urea; amino acids; and peptides like insulin and antidiuretic hormone (ADH) The volume of filtrate formed per unit time is known as the GFR In a normal young adult male, the GFR is an incredible 180 L/day (125 mL/min)! Contrast this value with the net filtration of fluid across all the other capillaries in the body: approximately 4 L/day The implications of this huge GFR are extremely important When we recall that the average total volume of plasma in humans is approximately 3 L, it follows that the entire plasma volume is filtered by the kidneys some 60 times a day The opportunity to filter such huge volumes of plasma enables the kidneys to excrete large quantities of waste products and to regulate the constituents of the internal environment very precisely One of the general consequences of aging and of many renal pathologies is a reduction in the GFR The forces that determine the GFR and their physiological control are described in s 2 and 7.

Hell, I can t just sit around and see an error being made and not say anything about it I like to think I ve had some experience in this business, and you don t win when you re making a lot of errors Nobody wants to be told they re making errors, not the way I tell them But they ve got to be told until they get to the point where they don t make them anymore

Filtered phosphate is normally the most important non-bicarbonate urinary buffer Most free plasma phosphate exists in a mixture of monovalent and divalent forms In Equation 9 5, monovalent dihydrogen phosphate (on the left) is a weak acid, and divalent monohydrogen phosphate (on the right) is its conjugate base

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Unlike desktop computers, which are fairly homogenous, the purchase of mobile computers involves many decision factors, many of which are outlined and explained in greater detail in the sections below Each of these criteria should be evaluated in terms of your company s specific needs and requirements to determine the best fit Mobile device costs can vary greatly from a $200 phone or pager to a $7,500 rugged laptop computer Therefore, you should carefully evaluate your needs, with an eye to scaling and expansion Don t be quick to make a choice Remember that the differences between thin and intelligent mobile device (discussed in 7) have a direct impact on the system architecture and application design An error in device choice can be quite costly since it could cost system redesign and application recoding

And then, an hour later or a day later, he d be patting that same player on the back, telling him that things were going well and that there were no hard feelings In many of those cases, I think he realized he had gone too far, and now it was time to rebuild some bridges If I yell at someone, he used to say, five minutes later I don t know what I said or who I said it to And that was true, as far as it went, although there were many times at home when I could only wish he was that quick to forget! Other times, I think, the Lombardi roller-coaster ride was far more deliberate He was determined to get the last 10 percent out of people, and sometimes an emotional explosion was the best way to accomplish that This approach flies in the face of most modern motivational theory, which argues that criticism should be private and applause should be public Many a Packer (and later a

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