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intercalated cell (Figure 9 5) Within the cytosol, hydrogen ions and bicarbonate are generated via carbonic anhydrase However, the H-ATPase pump is located in the basolateral membrane, and the Cl-HCO3 antiporter is in the luminal membrane Accordingly, bicarbonate moves into the tubular lumen, whereas hydrogen ion is actively transported out of the cell across the basolateral membrane and enters the blood, where it can combine with a bicarbonate ion Thus, the overall process achieves the disappearance of excess plasma bicarbonate and the appearance of bicarbonate in the urine, with resulting acidification of the plasma and alkalinization of the urine and maintenance of bicarbonate balance How do the kidneys excrete an acid load For all individuals who ingest animal protein of any kind, excretion of excess acid is more typical than the production and removal of excess base This is a more complex process than excretion of base, but it obeys the principles we have developed earlier Recall that the net result of addition of acid to the body reduces the amount of bicarbonate on an almost mole-for-mole basis Therefore, the task for the kidney is to replace the lost bicarbonate by generating new bicarbonate from CO2 and water (being careful to excrete the hydrogen ion that is created at the same time) In essence, the process is as follows: Hydrogen ions and bicarbonate are produced from carbon dioxide and water within cells Hydrogen ions are secreted and combine with the conjugate base of buffers in the tubular lumen other than bicarbonate, thereby generating the acid form of the buffer The acid form of that buffer is excreted in the urine The process of producing and secreting hydrogen ions generated new bicarbonate that goes into the blood and replaces the bicarbonate lost when the acid load entered the body The key is generation of new bicarbonate to replace the bicarbonate that was lost If we just reabsorb filtered bicarbonate, nothing is changed We must generate new bicarbonate.

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It is impossible to design a system that will improve productivity and enhance communication and customer service without first developing an indepth understanding of the current business processes Once again, this system is more than an application development project; it may, in effect, re-architect the operational processes within the business unit This is just another reason why it is critical to make sure members from the operational staff, business unit management, and end users are all on your project team

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You can t coach without criticizing, and it s essential to understand how to criticize each man individually For instance, some can take constructive criticism in front of a group, and some can t Some can take it privately, but others can only take it indirectly Football is a pressure business, and on my teams I put on most of the pressure The point is that I ve got to learn 40 ways to pressure 40 men

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We emphasized earlier how hydrogen ion secretion achieves bicarbonate reabsorption and how this process prevents loss of filtered bicarbonate Now we see that the identical transport process of hydrogen ion secretion can also achieve acid excretion and addition of new bicarbonate to the blood At first glance, this seems like a contradiction: How can the same process produce 2 different end results The answers lies in the fate of the hydrogen ion once it is in the lumen If the secreted hydrogen ion combines with bicarbonate, then we are simply replacing bicarbonate that would have left the body In contrast, if the secreted hydrogen ion combines with a non-bicarbonate buffer in the lumen (or, to an extremely small degree, remains free in solution), the hydrogen ion is excreted The bicarbonate produced in the cell and transported across the basolateral membrane is new bicarbonate, not a replacement for existing bicarbonate There are two sources of tubular non-bicarbonate buffers: filtration and synthesis Normally, the most important of the filtered buffers is phosphate, while ammonia is the most important synthesized buffer Ammoniagenesis is crucial to renal acid excretion because its rate can be greatly increased in the face of large acid loads, whereas the availability of filtered buffers, while somewhat variable, is

In other words, my father had a mental inventory of all of his players and a clear sense of how to pressure (or motivate) each of them For example, Henry Jordan had a problem with complacency

The first step in developing a new business process specification is to identify operational goals for the new system and document the current business practices Some of this information may already have been collected by the team driving the project when it developed a business case to receive management buy-in These steps are sometimes blurred For our purposes, we are assuming that management has already committed and bought into the vision and objectives of the project, and now it is up to you to implement it The process chart in Figure 82 depicts the various steps that will be covered in the next sections of this chapter

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[Jordan] has a tendency to be satisfied, which is why I don t flatter him much, and why often, when we re reviewing the pictures, I make him a target Sometimes you will make a man a target to impress somebody else who can t accept public criticism, but I will call Hank because we both know his ability and know that I m on him to bring it out, and because he performs best when he s just a little upset

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