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Compared to penile erection much less research has been conducted in anesthetized animals in order to elucidate the physiology and the pharmacology of ejaculation However, four interesting paradigms have been developed: 1 Urethrogenital re ex: the urethrogenital (UG) re ex is elicited by mechanical stimulation of the urethra in anesthetized and spinalized rat Such a stimulation causes a spinal re ex to occur that consists of rhythmic contraction of the bulbospongiosus (BS) and the ischiocavernosus (IC) striated muscles associated with penile erection It may be considered as mimicking the expulsion phase of ejaculation 2 PCA-induced ejaculation: A model of pharmacologic induced ejaculation; p-chloroamphetamine (PCA) is an amphetamine derivative that liberates catecholamines and serotonin (5-hydroxytrptamine, 5HT) from monoaminergic nerve terminals Systemic administration of PCA has been reported to induce ejaculation in both conscious and anesthetized rats Pharmacologic data indicate that the primary role in mediating the effect of PCA on ejaculation involves 5-HT, whereas noradrenaline (NA) appears to be of secondary importance 3 Electrical stimulation of peripheral nerves and ejaculation: in anesthetized rats, electrical stimulation of the hypogastric nerve can partially reproduce the ejaculatory process, ie eliciting a rise in seminal vesicle and bladder neck pressures that correspond respectively to seminal vesicles contractions and closure of the bladder neck, but it fails to induce the expulsion re ex 4 Pudendal motoneuron re ex discharge: the recording of electrical activity in the efferent branch of the ejaculatory re ex, ie the pudendal motor response discharge (PMRD) elicited by the electrical stimulation of the afferent branch of the expulsion re ex the dorsal nerve of the penis, is thought to be an experimental model representing events that occur in humans during sexual intercourse and that culminate with the expulsion of sperm

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