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The history of apomorphine dates back to 1869 when its rst synthesis from morphine was reported by Mathiessen [15] The dopaminergic activities of apomorphine were rst published in the mid 1960s when it was successfully administered in Parkinson s disease to suppress refractory motor oscillations [16] Apomorphine was formerly used as an emetic in the treatment of poisoning to prevent absorption of orally ingested poisons The erection-inducing effect of apomorphine in humans was rst described by Lal et al [17] In 1995 Heaton et al reported positive results for orally administered apomorphine in seven out of 10 patients with psychogenic impotence [18]

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A compilation is limited to presenting in the form of a personal nancial statement(s) information that is the representation of the individual The nancial statement(s) have not been audited or reviewed and, accordingly, the accountant does not express an opinion or any other form of assurance on them (SSARS No 1, paragraph 14, modi ed for personal nancial statements)

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Although apomorphine SL has shown statistically signi cant ef cacy vs placebo in the phase II/III clinical program, the net bene t ratio (active ef cacy minus placebo ef cacy) with gures between only 11 and 13%, were not convincing at all [27,28] This limited ef cacy of apomorphine SL, especially in organic ED, was recently con rmed in 130 diabetic ED patients in whom apomorphine SL 3 mg resulted in response rates of 229% vs 173% for placebo [29] Meanwhile several prospective studies between apomorphine SL and sildena l were reported in the literature, with all of them resulting in a highly statistically signi cant superiority of sildena l, and preference rates of 94 95% in favour of sildena l [30 32] Due to that overwhelming superiority of PDE-5 inhibitors, apomorphine SL never reached noteworthy acceptance or reasonable market shares in those countries where it was approved; meanwhile the drug marketed as Uprima was withdrawn from nearly all markets in Europe, except in the UK where it is still marketed as 3 mg tablets

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Any other procedures the accountant performs in connection with the engagement should not be mentioned in the report The compilation report is addressed to the individual whose nancial statement(s) are compiled and the date of the report is the date of the completion of the compilation procedures Also, each page of the statement of nancial condition (and the statement of changes in net worth, if presented) should include a reference See Accountant s Compilation Report (b) REPORTING WHEN SUBSTANTIALLY ALL DISCLOSURES ARE OMITTED An accountant may be asked to compile personal nancial statements that omit substantially all disclosures required by GAAP (SOP 82 1), including disclosures that might appear in the body of the statements Such reporting is appropriate provided the omission of the disclosures is clearly indicated in the accountant s compilation report and the accountant is not aware that the disclosures are being omitted for the purpose of misleading the intended users of the statements For example, it would not be appropriate to omit from personal nancial statements intended for use in obtaining a home mortgage informative disclosures that would be important to the nancial institution in making the loan decision If disclosures are omitted, and certain selected information is presented in the footnotes, for example, information important in obtaining a mortgage loan, such information should be labeled Selected Information Substantially All Disclosures Required by GAAP Are Not Included If substantially all disclosures are omitted from the personal nancial statements and the statements do not disclose that the assets are presented at their estimated current values and that the liabilities are presented at their estimated current amounts, the accountant should include this disclosure in his or her compilation report If the statements have been presented on a comprehensive basis of accounting other than GAAP, that basis of accounting, if not disclosed in the statements, must be included in the accountant s report (c) REPORTING WHEN THE ACCOUNTANT IS NOT INDEPENDENT An accountant may issue a compilation report on the personal nancial statements of an individual even though he or she is not independent with respect to that individual In such cases, the accountant must modify the compilation report The speci c reason or reasons for the lack of independence, such as a family relationship, need not be discussed The accountant should add an additional paragraph to the compilation report stating:.

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